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Clinical resources

Adapting for positive outcomes

PICO sNPWT has a strong evidence base

  • 103* published papers of which 65 are clinical studies
    (including 4 NPWT meta-analysis which note PICO sNPWT)
  • Total published RCTs = 20†

 

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*To 23rd January 2019.
†11 level 1 RCTs, 9 level 2 RCTs.

Negative pressure wound therapy for management of the surgical incision in orthopaedic surgery

A key window has been identified during which post-operative prophylactic treatment of surgical incisions with negative pressure wound therapy has been shown to minimize complications. Orthopaedic surgeon S. Karlakki, working with several other contributors, reviewed the literature from the past few year to discover a rapidly emerging, effective trend. Their findings were published in the Bone Joint Res 2013.

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The effectiveness of a sNPWT system, compared to tNPWT in the treatment of chronic ulcers of lower extremities — Kirsner et al. (2018) Multi-center, phase 4, randomized, comparative efficacy study.

A recent RCT to compare the percentage change in target ulcer dimensions (area, depth, volume) in lower extremity wounds (VLU/DFU) (www.clinicaltrials.gov) when comparing PICO NPWT to tNPWT. The exciting conclusion was, PICO demonstrated superior wound closure rates of DFUs and VLUs, combined, over 12 weeks compared to tNPWT. In the original randomized controlled trial, results were statistically significant for DFUs alone, and DFUs and VLUs combined. Consideration: filler utilization was not assessed during this study. Click on the poster to see the full details of the study.

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